• A case-control study found that one in seven patients with a first acute ischemic stroke tested positive for one of the inherited thrombophilias, but that the relationship was likely to be coincidental rather than causal in almost all cases.
• In a systematic review, the prevalence of inherited deficiencies of protein C, protein S, antithrombin III, or plasminogen was low in unselected patients with ischemic stroke.
• The pretest probabilities of other coagulation defects in these patients were as follows:·
• Lupus anticoagulant 3 percent (8 percent in patients ≤50 years)
• Anticardiolipin antibodies 17 percent (21 percent in patients ≤50 years) (cardiolipin ab)
• Activated protein C resistance/factor V Leiden mutation 7 percent (11 percent in patients ≤50 years)
• ·Prothrombin mutation 5 percent (6 percent in patients ≤50 years)