Reverse of anticoagulation

Reversal of anticoagulation in Warfarin associated intracerebral hemorrhage

UptoDate

= Vit K iv - 10 mg at 1 mg/minute, will reverse in 12-24 hr.
- May repeat vit K q12 hours for persistent inr elevation
= PCC 4 factor 2000 IU at 100 IU/minute
or PCC 3 factor 2000 IU at 100 IU/min
or FFP 4 units
= check inr q6 x 24 hours, then qd, until less than 1.4

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