NSAID

Non Steroid Anti-inflammatory

Generic Name (Brand)

Usual adult dose

COX- 2 inhibitor

Rofecoxib (Vioxx)

Taken off market. To receive refund on Vioxx:

	1-800-805-9542
	www.vioxx.com

Celecoxib (Celebrex)

	Capsule: 100, 200 mg
	Usual dose: 100-200 mg qd

Valdecoxib (Bextra)

	Comes in 10, 20 mg
	Usual dose: 10-20 mg qd
	On November 13, 2002, Pharmacia, the manufacturer sent letters to health care professionals advising them of postmarketing reports and new warnings that will be included in the drug label. Since the firm began marketing the drug in March of 2002, cases of the serious skin and hypersensitivity reactions have been reported. These included cases of Stevens Johnson syndrome, toxic epidermal necrolysis, exfoliative dermatitis and erythema multiforme. Although these adverse events are rare, some of these patients required hospitalization. more information

Salicylates

Aspirin

650-1000 mg q4h

Choline magnesium trisalicylate (Trilisate)

	Less GI distress, longer half life than aspirin, and no significant platelet inhibition.
	Tab: 500, 750, 1000 mg.
	Dose: 1000-1500 mg bid

Salsalate (disalcid)

	Tab:500,750mg.
	Dose: 1000-1500 q6

Diflunisal (Dolobid)

Tab: 250, 500 mg. Take 1000 mg initial, then 500 mg bid

Sodium salicylate

325-650mg q3-4h

Propionic acid derivatives

Fenoprofen Calcium (Nalfon)

cap: 200, 300 mg. Tab: 600 mg. Use: 200-300 mg q4-6 h

Ibuprofen (Motrin)

400 mg q 4-6 h

Ketoprofen (Orudis) (Oruvail, extended release cap)

Cap: 25, 50, 75 mg. Use 25-75mg q6-8h

Ketoprofen (Oruvail, extended release cap)

cap: 100, 150, 200. use 100-200 mg qd

Naproxen (Naprosyn)

tab: 250, 375, 500 mg. Use 500 mg initial, then 250 mg q6-8h

Naproxen (EC-Naprosyn)

tab:375, 500mg. Use 1 tab bid

Naproxen sodium (Anaprox, Naprelan)

tab:275, 550. use 550 mg initial, then 275 mg q6-8h

Indoleacetic acid derivatives

Indomethacin (Indocin, Indocin SR)

	Promotes urinary excretion of uric acid, used to manage gout
	GI side effect frequent, may also cause psychosis, headache, depression, hypertension and fluid retention.
	cap: 25, 50, suppository: 50 mg, SR: 75 mg
	dose: 75-150 mg/day for short term use

Sulindac (Clinoril)

	fewer side effect than Indmethacin
	tab: 150, 200 mg
	dose: 150-200 mg bid

Etodalac (Lodine)

	Cap: 200, 300 mg, Tab 400, 500 mg.
	Dose: 200-400 mg q6h

Tolmetin (Tolectin)

tab/cap: 200, 400, 600 mg
dose: 400 mg tid, up to 1800 mg/day

Fenamates

Mefenamic acid (Ponstel)

	Cap: 250 mg.
	dose: 250 mg q6 h

Meclofenamate sodium (Meclomen)

50 mg q 4-6 h

Benzothiazine derivatives or Oxicams

Mobic (meloxicam)

	Approved 2000
	Tablet: 7.5 mg
	Usual dose 7.5 mg tablet QD
	Complete prescribing information

Piroxicam (Feldene)

	tab: 10, 20 mg
	dose: 20 mg qd

Pyrrolacetic acid

Diclofenac (Volataren, Cataflam)

	tab: 50 mg
	50 mg tid or qid

Ketorolac (Acular, Toradol)

Oral must be used for < 5 days

10 mg q6-8h

Parenteral use < 48 hours

30-60 mg IM, then 15-30 mg q6h

boxed warning

Further readings

Improving outcome in Osteoarthritis - Postgraduate Medicine may 1999