| Symmetric Polyneuropathy |
 | symmetric, length-dependent involvement, with classic glove-and-stocking
pattern of sensory loss and distal weakness |
| has a long differential diagnosis. |
|
| Acute motor paralysis with minimal sensory
disturbance. |
| Guillain-Barré syndrome |
| Diphtheritic polyneuropathy |
|
| Subacute sensorimotor neuropathy |
| Nutritional deficiency:
 | alcoholism (beriberi), pellagra, vitamin B12 deficiency. |
|
| Heavy metals and solvents:
| arsenic, lead, mercury, thallium, methyl-n-butylketone, n-hexane, methyl
bromide, organophosphates, acrylamide. |
|
| Drug effects:
| isoniazid, ethionamide, hydralazine, nitrofurantoin, disulfiram,
vincristine, chloramphenicol, phenytoin, dapsone, etc. |
|
| Uremic neuropathy
| When creatinine clearance < 10% of normal, motor conduction velocity
slows. |
| Symptoms: unpleasant dysesthesia in the feet. |
| Rarely cause disabling motor weakness and autonomic involvement. |
|
|
| Chronic sensorimotor polyneuropathy. |
| Benign form in the elderly |
| Connective tissue diseases |
| Uremia (occasionally subacute) |
| Beriberi (usually subacute) |
| Carcinoma (paraneoplastic syndrome) |
| Paraproteinemias |
| Hypothyroidism |
| Amyloidosis
- Wash Univ |
| Diabetes |
| Leprosy |
| Hereditary (Charcot-Marie-Tooth and others) |
|
| Proximal + distal weakness + sensory loss |
| Inflammatory demyelinating polyneuropathy
|
|
| Symmetric sensory loss with no weakness |
| Chronic
crytogenic sensory neuropathy (CSPN) |
| Metabolic (Diabetes and others) |
| Drugs, toxins |
|
| Symmetric sensory loss + distal areflexia + UMN
signs |
| B12 deficiency and other causes of combined system degeneration with
peripheral neuropathy |
|
